Congratulations Dr. Kenji Kobayashi!

Kenji Kobayashi has officially received his Ph.D. He will be starting as a postdoc in the Gottlieb lab at Columbia in the spring. Congratulations Kenji! Now for the commencement photos. :)

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Welcome to Zhihao Zhang

Welcome to Zhihao Zhang to the lab as a postdoc fellow. Zhihao obtained his Neurobiology PhD at Yale School of Medicine. He will be jointly working with our lab and the Kayser lab on some exciting studies combining fMRI, pharmacology, and computational modeling.

New paper on honesty and deception

New paper offering a signaling perspective on studying the neural substrates of honesty and deception.

Jenkins, Adrianna, Lusha Zhu, and Ming Hsu. “Cognitive neuroscience of honesty and deception: A signaling framework.” Current Opinions in Behavioral Sciences.


US-France Collaboration Award

A US-France collaboration from NIDA has been awarded to support our work with Sacha Gironde at Jean Nicod Institute on understanding the computational substrates of monetary exchange.

Welcome to Zuzanna Balewski

Welcome to Zuzanna Balewski to the lab as a Neuroscience program rotation student. She will be working with Ignacio Saez on electrocorticography studies of economic decision-making.

Sackler Fellow Award to Ming Hsu

Ming Hsu just received a UC Berkeley-UCSF Sackler Program Fellowship to support translating basic neuroeconomic research to clinical applications. Prof. Hsu will be working with researchers at the UCSF Memory and Aging Center to improve current assessments of decision-making and social deficits, as well as to explore their commercial applications.

K01 Award for Ignacio Saez

Congratulations to Ignacio on his newly awarded K01 application, “Electrocorticography of human prefrontal cortex during value-based decision-making”!

New paper on culture and genes

Shinobu Kitayama, Tony King, Israel Liberzon, and I just had a review paper on the interaction between genes and culture accepted1. I'm not a cultural psychology researcher, and never thought about it much prior to talking to Shinobu. His paper on the relationship between rice and wheat cultivation on the one hand, and culture on the other, really changed how I think about the role of biology and culture.

Briefly, northern China largely relies on wheat-based cultivation, whereas souther China is largely rice-based. There are also pretty profound cultural differences. But up until now nobody bothered to quantitatively link the two and provide some rationale for why they might be connected. You'll have to read their paper for the full story, but for me it makes an incredible amount of sense, and also explains some of the regional stereotypes that every Chinese speaker would know by heart.

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The other benefit of thinking about behavioral consequences of culture is that it allows for a much more mechanistic conceptualization of the effects of genes on culture, which is what our paper discusses. Below is one of the figures from the paper that tries to capture why social scientists interested in culture should care about biology, and why biological researchers should care about culture. Obviously this is incomplete and missing many important details, but given that culture is typically thought of as a nuisance variable in genetic and biological research, this is already an important step forward.

1 Kitayama, Shinobu, Anthony King, Ming Hsu, and Israel Liberzon. “Dopamine-System Genes and Cultural Acquisition: The Norm Sensitivity Hypothesis.” Current Opinion in Psychology.

Haas Profile of Lab Research

Haas Now just posted a profile on some of our recent research, and how they might change the future of business and marketing. If you are too lazy to read the whole thing, this is the one sentence summary of why businesses should care about what we are trying to do.

People say a lot of things, a lot of which are true but some are not. We want to develop ways to separate these.

New paper on neuroeconomics and neurology

My collaborators at UCSF's Memory and Aging Center just had a paper accepted in Brain, where we applied neuroeconomic tools to characterize behavioral deficits in frontotemporal dementia patients. Behavioral and social dysfunctions are some of the most difficult to capture quantitatively, even though they are often the most visible symptoms to family and loved ones. Hopefully we will be able to finally make some inroads given all that we have learned in neuroeconomics in the past decade.

Chiong, Winston, Kristie Wood, Alexander Beagle, Ming Hsu, Andrew Kayser, Bruce Miller, and Joel Kramer. “Neuroeconomic dissociation of semantic dementia and behavioral variant frontotemporal dementia.” Brain.

Early Career Award to Ming Hsu

Prof. Ming Hsu received the Early Career Award at the 2015 Society for Neuroeconomics conference!

Welcome Nick Angelides and Paul Krueger

Welcome Nick Angelides and Paul Krueger to the lab!

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Nick is starting as a PhD student in the Cognitive Neuroscience group in Psychology. Nick received his B.A. from Rutgers University and M.St. from the University of Oxford. He joins us after working with the lab of Tim Vickery on economic decision-making. He is interested in the intersection of social and economic decision-making. His research aims to characterize the neural mechanisms underlying competitive and cooperative behavior using machine learning pattern classification methods, and modulating dopamine systems using pharmacological tools.

Paul is also starting as a PhD student in the Cognitive Neuroscience group in Psychology. Paul received his B.A. from Princeton where he worked in the lab of Jonathan Cohen. Uniquely among psychology students, Paul is putting together his own lab rotation, where he will be working with Sonia Bishop and Rich Ivry.

NiB: Neuroscience in Business Schools

Along with Uma Karmarkar, Vinod Ventrakamen, and Carolyn Yoon, we have started a group to connect neuroscience researchers in business-related fields. The idea came from a conversation we had at the 2014 Association for Consumer Research meetings on how to promote neuroscience research in consumer research and marketing. Among the many challenges, two in particular seemed ripe for tackling with something as simple as a mailing list.

First, a neuroscientist in a marketing department will likely find him/herself to be the first and only one there. More importantly, interdisciplinary fields inevitably result in mixing of researchers coming from very different backgrounds, especially when we consider across business-related disciplines, for example between marketing, management, finance.

To address this, we created a Neuroscience in Business google group to connect neuroscience researchers in business-related fields, and to provide a resource for those interested in the area. To add please go to the webpage to sign up. Below is a brief description.

Welcome to Neuroscience in Business (NiB)! This is a group for connecting academics in business schools who are using neuroscience methods, created by Ming Hsu, Uma Karmarkar, Vinod Ventrakamen, and Carolyn Yoon. The use of neuroscientific theories and tools in business research is growing rapidly, but is still quite novel for many business schools. In addition, people in these areas may come from very different disciplinary backgrounds. We aim to build stronger bonds in this community and increase the potential for collaboration, sharing resources, and improving training, by connecting researchers in various business-related fields who are incorporating theories and data from the biological sciences. Please join us if you are either (i) a researcher in a business-related field using (or looking to use) neuroscience theories and data in your research, or (ii) a researcher in the biological sciences working on business-related topics of interest.

Lake Tahoe Lab Retreat

The lab taking a well-deserved couple of days off during our lab retreat at Tahoe.


Lab Retreat (Lake Tahoe, June 4-5, 2015
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Congratulations Dr. Yuping Chen!

Our own Yuping Chen has officially received her Ph.D. She will be starting in the fall as assistant professor of marketing at College of Management, National Taiwan University! Congratulations Yuping!

New paper on decoding brand personality

Congratulations to Yuping Chen, whose paper has been conditionally accepted at Journal of Marketing Research! The study used fMRI and model-based MVPA methods to decode consumers' thoughts to well-known commercial brands.

From “Where” to “What”: Distributed Representations of Brand Associations in the Human Brain

Yuping Chen, Leif Nelson, and Ming Hsu

Considerable attention has been given to the notion that there exists a set of human-like characteristics associated with brands, referred to as brand personality. Here we combine newly available machine learning techniques with functional neuroimaging data to characterize the set of processes that give rise to these associations. We show that brand personality traits can be captured by the weighted activity across a widely distributed set of brain regions previously implicated in reasoning, imagery, and affective processing. That is, as opposed to being constructed via reflective processes, brand personality traits appear to exist a priori inside the minds of consumers, such that we were able to predict what brand a person is thinking about based solely on the relationship between brand personality associations and brain activity. These findings represent an important advance in the application of neuroscientific methods to consumer research, moving from work focused on cataloguing brain regions associated with marketing stimuli to testing and refining mental constructs central to theories of consumer behavior. 


New article on causal effect of dopaminergic drug on inequity aversion

Congratulations to Ignacio, our paper on the causal involvement of prefrontal dopamine has just been accepted at Current Biology!

Egalitarian Behavior in Humans

Ignacio Saez, Lusha Zhu, Eric Set, Andrew Kayser, and Ming Hsu

Egalitarian motives form a powerful force in promoting prosocial behavior and enabling large-scale cooperation in the human species. At the neural level, there is substantial, albeit correlational, evidence suggesting a link between dopamine and such behavior. However, important questions remain about the specific role of dopamine in setting or modulating behavioral sensitivity to prosocial concerns. Here, using a combination of pharmacological tools and economic games, we provide critical evidence for a causal involvement of dopamine in human egalitarian tendencies. Specifically, using the brain penetrant catechol-O-methyl transferase (COMT) inhibitor tolcapone, we investigated the causal relationship between dopaminergic mechanisms and two prosocial concerns at the core of a number of widely used economic games: (1) the extent to which individuals directly value the material payoffs of others, i.e., generosity, and (2) the extent to which they are averse to differences between their own payoffs and those of others, i.e., inequity. We found that dopaminergic augmentation via COMT inhibition increased egalitarian tendencies in participants who played an extended version of the dictator game. Strikingly, computational modeling of choice behavior revealed that tolcapone exerted selective effects on inequity aversion, and not on other computational components such as the extent to which individuals directly value the material payoffs of others. Together, these data shed light on the causal relationship between neurochemical systems and human prosocial behavior and have potential implications for our understanding of the complex array of social impairments accompanying neuropsychiatric disorders involving dopaminergic dysregulation.

Gene learning paper in Berkeley Science Review

Kevin Doxzen from Berkeley Science Review has written a fantastic piece about our genetic basis of strategic learning paper. The best part is that Kevin in his day job is a biophysicist, which allowed me to geek out a bit during the interview. Luckily he also translated most of that into language normal people speak. :)

New article on causal involvement of DLPFC in honesty

Our paper on the causal involvement of DLPFC in honesty has just been accepted at Nature Neuroscience! This will hopefully be one in a long line of papers by us and others applying signaling games to the study of honesty and deception.

Damage to dorsolateral prefrontal cortex affects tradeoffs between honesty and self-interest

Lusha Zhu, Adrianna C Jenkins, Eric Set, Donatella Scabini, Robert T Knight, Pearl H Chiu, Brooks King-Casas, and Ming Hsu

Substantial correlational evidence suggests that prefrontal regions are critical to honest and dishonest behavior, but causal evidence specifying the nature of this involvement remains absent. We found that lesions of the human dorsolateral prefrontal cortex (DLPFC) decreased the effect of honesty concerns on behavior in economic games that pit honesty motives against self-interest, but did not affect decisions when honesty concerns were absent. These results point to a causal role for DLPFC in honest behavior.

Welcome Lekha Viswanadham

We have a new addition to the lab this summer. Lekha Viswanadham is joining us from Caltech as part of the SURF program. She will be working with us this summer on developing novel methods for genetic and imaging genetic analysis of behavior. Welcome Lekha!